Abstract K-mer based methods have become prevalent in many areas of bioinformatics.In applications such as database search, they often work with large multi-terabyte-sized datasets.Storing such large datasets is a detriment to tool developers, tool users, and reproducibility efforts.General purpose compressors like gzip, or those designed for read
Battery electric vehicles (BEVs) have received increasing attention in recent years as BEV technical capabilities have rapidly developed.While many studies have attempted to investigate the societal impacts of BEV adoption, there is still a limited understanding of the extent to which widespread adoption of BEVs may affect both environmental and ec
Herein, the effect of silymarin pretreatment on the pharmacokinetics of simvastatin in rats was evaluated.To ensure the accuracy of the results, a rapid and sensitive UPLC−MS/MS method was established for simultaneous quantification of simvastatin (SV) and its active metabolite simvastatin acid (SVA).This method was applied for studying the p
Summary: Droplet-based single-cell RNA-seq (scRNA-seq) data are plagued by ambient contaminations caused by nucleic acid material released by dead and dying cells.This material is mixed into the buffer and is co-encapsulated with cells, leading to a lower signal-to-noise ratio.Although there exist computational methods to remove ambient contaminati